What is the recommended dose for epinephrine in patients requiring vasopressor support?

The recommended dose for epinephrine in patients requiring vasopressor support is typically established at a range of 2-10 mcg/min by IV infusion. This dosage is effective for increasing vascular resistance and improving cardiac output during situations like septic shock or severe hypotension, where vasopressors are often indicated.

Epinephrine works by stimulating alpha-adrenergic receptors, which leads to vasoconstriction, and beta-adrenergic receptors, which support cardiac contractility and heart rate. The specified range of 2-10 mcg/min provides a balance that can help manage blood pressure effectively while minimizing the risk of adverse effects associated with higher doses, such as excessive vasoconstriction and potential ischemia.

In clinical practice, initiating treatment within this recommended dose range allows healthcare providers to monitor the patient's response and adjust the infusion rate as needed to achieve optimal hemodynamic stability. This method of titration is essential in critical care scenarios, where patient responses can vary significantly.