After administering naloxone for suspected opioid overdose, how long should the healthcare team wait before administering a second dose if there is no response?

When administering naloxone for suspected opioid overdose, the recommended waiting period before administering a second dose if there is no response is generally 2 minutes. This timeframe allows for ample assessment of the patient's response to the first dose, as the onset of action for naloxone typically occurs within minutes.

During this window, healthcare providers can monitor vital signs and overall responsiveness to determine if further naloxone is needed. If no improvement is observed after 2 minutes, a repeat dose is justified, as this can be critical in reversing the effects of opioids and improving the patient's condition. Administering a second dose too quickly might not provide sufficient time to accurately gauge the effectiveness of the first dose, which is why the 2-minute interval is the standard guideline in practice.